منابع مشابه
Statin adverse effects: sorting out the evidence.
CASE u carl l, a 57-year-old obese patient (body mass index [Bmi] >40) who had not been to a doctor in a decade, comes to see you after a health fair screening revealed dyslipidemia (low-density lipoprotein [lDl] cholesterol, 188 mg/dl; high-density lipoprotein cholesterol [hDl], 32 mg/dl; total cholesterol, 240 mg/dl; triglycerides, 100 mg/dl). his blood pressure (Bp) is 146/90 mm hg and his f...
متن کاملPhenotyping Adverse Drug Reactions: Statin-Related Myotoxicity
It is unclear the extent to which best practices for phenotyping disease states from electronic medical records (EMRs) translate to phenotyping adverse drug events. Here we use statin-induced myotoxicity as a case study to identify best practices in this area. We compared multiple phenotyping algorithms using administrative codes, laboratory measurements, and full-text keyword matching to ident...
متن کاملMisinterpretation of trial evidence on statin adverse effects may harm patients.
Finegold et al., in their article, interpret the absence of average difference in rates of published adverse effects (AEs) for statins vs placebo in industry-funded randomized controlled trials (RCTs) as meaning that statins have approximately no side effects. This shows a lack of understanding of critical issues of effect modification, selection bias, and selective publication that have repeat...
متن کاملStatin-Associated Side Effects.
Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well tolerated, but associated with various statin-associated symptoms (SAS), including statin-associated muscle symptoms (SAMS), diabetes mellitus (DM), and central nervous system complaints. These are "statin-associated symptoms" because they are rare in clinical trials, making their causative relationship to sta...
متن کاملStatin associated hepatic adverse effects: a retrospective review from a regional hospital in sultanate of oman.
OBJECTIVE This study aimed at evaluating the prevalence, pattern and predisposing factors for hepatic adverse effects with statins in a regional hospital in Sultanate of Oman. METHODS A retrospective review of the patient files in Department of Medicine during the year 2011 was done to evaluate any hepatic dysfunction possibly related to statins among the patients. For each case of suspected ...
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ژورنال
عنوان ژورنال: American Journal of Cardiovascular Drugs
سال: 2008
ISSN: 1175-3277
DOI: 10.2165/0129784-200808060-00004